Contact Information
Name: Claudia G. Lucero, PhD
Title: Associate Professor of Chemistry
Office Location: TSC 2017
Email: cglucero@csus.edu
Office Phone: 916.278.6006
Mailing Address: 6000 J street
Office Hours: T-Th 10:30am -12pm
Biography
Dr. Claudia G. Lucero is originally from Los Angeles, California. Graduated from UC Berkeley in 1994 with a B.S. in Chemistry, pursued a PhD at UC Irvine and completed her post-doctoral work at Boston college. She began her independent career in 2008 at CSU Sacramento.
Curriculum Vitae : l/cglucero/images/cv20191.doc
Teaching Fall 2019:
Chem 124 Syllabus l/cglucero/images/chem124syllabusfall2019.pdf
Chem 25 Syllabus l/cglucero/images/chem25syllabusfall2019.pdf
Research Projects/Publications
Our goal is to execute the first total synthesis of lorneic acids in as few as three steps.
Preliminary results have shown that two of the previously synthesized lorneic acids A and B possess phosphodiesterase inhibitory activity. Phosphodiesterase inhibition is of major interest in the pharmaceutical industry. Phosphodiesterase enzymes cleave the phosphodiester bonds in secondary intramolecular messengers like cyclic-AMP and cyclic-GMP, which are involved in many biological processes that include glycogenolysis, cellular apoptosis. These secondary messengers are also involved in smooth muscle tissue relaxation, and blood vessel vasodilation. This provides a motivating force to synthesize the new eight lorneic acids as they may also possess similar biological activity. The potential inhibitory activities of the lorneic acids on phosphodiesterase can prevent degradation of secondary messengers and provide physiological processes to continue efficiently.
Previous work: Total sytheses of Tatarinoid A, B and C. Click on links for publications
Research Group members
Graduate Students
Daniel Orozco
Undergraduate Students
Joshua Braafladt
Selene Gonzalez
Alana Webb
Wisam Morrar
Previous Research Students
Research Space
Fellowships & Grants
GRANTS RECEIVED
• Summer Undergraduate Research Experience (SURE) Award, “Total Synthesis of Lorneic Acid F.” $9,500 (Summer 2019)
• Research and Creative Activity Mini-Grant Program, $2758.22 (2014-2015)
• CSU Program for Education and Research in Biotechnology (Presidents’ Commision Scholars Grant Program), “Total Synthesis of (-)-Tatarinoid B.” $8,000. (Summer 2012)
• CSUS Faculty Promotion Development Funds, $500. (2011-2012)
• University Enterprises, Inc. (UEI) Faculty Grants Program Award, $1000. (2011-2012)
• National Science Foundation, Major Research Instrumentation (NSF-MRI). “Acquisition of a 500 MHz NMR Spectrometer for Research at CSU Sacramento.” $655,000 (2009-2012)
• CSU Program for Education and Research in Biotechnology, “Catalytic Enantioselective 1,4-Additions of Allyl Indium Reagents to a,b-Unsaturated Aldehydes.” $15,000. (2011-2012)
• CSUS Faculty Promotion Development Funds, $500. (2010-2011)
• University Enterprises, Inc. (UEI) Faculty Grants Program Award, $750. (2008-2009)